Ultrasound is used in medicine for imaging, therapy and for measurement of blood velocity. The use of this low energy, non-ionising waveform means that ultrasound exposures are thought to be less hazardous than other imaging modalities, though mild local tissue heating occurs with absorption of ultrasound energy. Ultrasonic vibration is defined as being in the bandwidth of 20 kHz to the MHz range, above human hearing ability. An ultrasound probe or transducer consists of a piezoelectric crystal, which mechanically generates and transmits a vibrating pressure wave in a tissue in response to an alternating electrical input (Fig 1A). Conversely, it also transduces an alternating electrical output in response to a vibrating pressure wave input from the tissue. Hence, the piezoelectric crystal can be used both to transmit a pressure wave and to detect a reflected wave (Fig 1B). The reflection of the ultrasound wave at the interface between two tissues of different densities, or at tissue...